Highlights
- Simple – No staining or sample preparation
- Fast – Results in as little as 10 secs
- Unique – cell volume based detection and aggregation correction
- Reliable – highest reproducibility even in critical applications (PBMC, Cell- & Immunotherapy, stem cell research, biomanufacturing, …)
- Modular – configure your CASY just the way you need it
- Cell QC – viability, cell size distribution (0,7-120um)
Globally, thousands of users, industrial and academic, trust CASY, the legend in cell counting. Whether working with mammalian cells, yeast, bacteria or one of many other cell types, CASY users rely on the unmatched precision, reproducibility and accuracy of the instrument combined with easy and intuitive use.
Why CASY provides superior performance
CASY uses Electronic Current Exclusion (ECE) technology. During measurement, each particle, nuclei or cell passing through the defined pore generates an electronic signal. The intensity correlates directly with their size and conductivity.
Electronic Current Exclusion means that CASY uses a frequency of 1 MHz for detection of cells passing the pore and integrates the signal over time of passage. As a result, CASY detects precisely the volume of cells, independent of their shapes.
Viability: Viable and Dying/Dead cells are detected with different volumes. Viable cells, with a polarized membrane generate a high resistance signal correlating with the full volume of the cell. Dying or dead cells display a much lower resistance due to their depolarized or fully disrupted cell membrane.
Aggregation correction: CASY provides a large dynamic measuring range, which ranges from small debris to even large aggregates of cells. Aggregates are detected precisely by their total cell volume which allows calculation of the number of single cells they include.
Flexibility: CASY can be used for a large variety of sample types including Bacteria, Yeast, Algae and Protozoa, Platelets, PBMC, various Mammalian, different StemCells and more. Additionally CASY can be customized to individual needs – please contact us for more details.
Reliability and Precision: Several thousands of cells detected in a single measurement in no time are the basis for CASY’s highest reproducibility and reliability. Even working with replicates and mean results are options of the new CASY software. Try yourself and compare with other counting methods.
We have been using CASY for the fast and reliable determination of cell concentrations and cell diameters of our cell cultures for 20 years now. We are still impressed by the high reproducibility of the measurements and the simple, intuitive operation of the device. The associated software offers great options for managing and displaying the measurement results graphically.
We study the regulation of cancer cell growth by signaling and metabolism. CASY is the ideal system for us to precisely measure proliferation and cell size of a wide range of cell lines. In this context, the new software makes instrument operation as well as data visualization and organization easy and convenient.
We use CASY cell counter for toxicological studies at a single animal level. The CASY cell counter proved to be an accurate and sensitive instrument for ecotoxicological applications allowing fast, simple and label-free measurements.
Cytotoxicity Assays using CASY enable us to perform fast, simple and reliable assessment of anti-cancer drug regimens and the subsequent chemosensitivity of carcinoma cell lines. A major advantage of CASY is that debris and dead cells can be masked in the analysis by a simple cell line specific setup and only viable cells and their aggregates are considered. However, as a complete cell status is recorded, also dead cells and debris data are available at any time.
Advantages of the CASY-Technology
- Dye-free – no sample preparation
- High resolution size distribution
- Highly accurate direct volume measurement
- Volume based aggregation correction
- Sensitive detection of alteration in cell sizes
- Low sample volume and short measuring time (from 10 sec)
- High accuracy (+/- 2 %) and repeatability
- Low running costs
- From R&D to Manufacturing QC
- Automatic electronic control of all critical parameters
- GLP/GMP compliant
- 21 CFR Part 11 (optional)
Upcoming CASY events
Currently there are no upcoming events. Have a look at our overview of all events.
Consumables
| Name | Article Number | Description | Quote | Order |
|---|---|---|---|---|
| CASYton | 5651808 | Isotonic measurement buffer for all CASY models. Politainer for easy filling of consumption quantities, 1x 10 L, | Quote | Order now |
| CASYcups | 5651794 | Measuring vessels for all CASY models. For dilution of the samples to be measured with CASYton and performing the cell count. 1 pack = 1800 cups, | Quote | Order now |
| CASYclean | 5651787 | Capillary and system cleaning agent for all CASY models. To be used for acute decontamination and routine cleaning. 1 x 500 mL | Quote | Order now |
| CASYblue | 5651760 | Solution for controlled killing of cell culture cells for accurate adjustment of the left cursor evaluation, 4 x 30 mL | Quote | Order now |
Downloads
General
CASY Operators Guide
Operators Guide
Keratinocytes CASY Tech Note
Simple but reliable: How even novice users receive best results with CASY
Appplication Note
Ecotoxicology: Algae Feeding Rates of Daphnia magna
Appplication Note
The Cytotoxicity of Anti-Cancer Drug Combinations
StartUp & ShutDown Instructions
StartUp & ShutDown Instructions
CASY results
Overview CASY results
Overview of all available CASY results
Algea and Protozoa
Set of CASY results for algea and protozoa
Bacteria
Set of CASY results for bacteria
Blood
Set of CASY results for blood cells
Cell Lines
Set of CASY results for various cell lines
Parasite
Set of CASY results for parasites
Platelets
Set of CASY results for platelets
Primary cells
Set of CASY results for primary cells
Stem Cells
Set of CASY results for stem cells
Get in touch
Britta Gerlach, PhD
Sales
Your Partner in Cell Research
Laufenstrasse 90
4053 Basel, Switzerland