High Content Screening Workstation


WiScan® Hermes - The ultimate cost-effective solution for high-content and high-throughput screening

Contact us

Request a Free Demo

Dedicated to high-content imaging and analysis for image-based assays in cell biology studies and drug discovery processes, the new High-Content Imaging System WiScan Hermes - brings publication-quality images at high-throughput speeds to the research lab.

High-Content Screening Workstation

High-Content Screening Workstation WiScan® Hermes

High-quality research needs high-quality devices and equipment. Advances in cellular and molecular biology studies have revolutionized the diagnosis and treatment of many different diseases. When it comes to diagnostics, a time-efficient high-quality diagnostic solution with software for cell counting and morphology, intracellular granules, cell counts and even protein expression levels.

When it comes to drug discovery processes, they are ideally combined with modern and innovative cell imaging techniques forhigh-throughput screening and imaging. Advances in computational sciences and machine learning algorithms have greatly served all biological sciences and allowed greater details to be dissected at a high throughput. From microbiology to immunooncology to cell culture, OLS provides you with your ideal imaging lab partner, the WiScan®Hermes High-Content Screening Workstation.

Hermes is a cost-effectiveHigh–Content/High–Throughput Screeningsystem that operates at extremelyhigh speedsof image acquisitionand generates veryhigh-quality images.

Whether you are performing assay development, compound screens, transfection assays or looking at a few samples in great detail, and whether you are using3D models(such as spheroids, organoids), zebrafish imaging, primary cells, fixed cells or live-cell imaging, WiScan® Hermes is the solution for you.

Highlights


  • Up to 7 colors + bright field
  • Magnification range 2x – 60x
  • Oil immersion
  • Use a variety of multi-well plates, slides, dishes
  • Modular platform

Push-button operation gives access even to novice users, while experienced microscopists will appreciate the comprising application-based image analysis tools of WiSoft Athena image analysis software.

Hermes WiScan operates at extremely high speeds of image acquisition! Multi-channel imaging of a 384-well plate with four colors is finalized after 5 min – in all ranges of magnification (2x – 60x), achieving an image resolution from 0.1 – 3 µm/pixel.

Scan a 96-well plate in less than 2 min, or a 1536-well plate in 20 mins.

Hermes is a high-end and sophisticatedmodular platform, offering modular optional packages, which enable full customization for different user requirements.

Time Lapse Experiments

Live-cell imaging gets feasible by the instrument’s environmental stabilization conditions. While the objectives are moved for scanning, the microplate remains fixed during the assay.

Object Mapping

Smart object mapping further enhances throughput: at a low magnification, whole wells are scanned quickly to identify areas of interest. Then, these areas are imaged at a higher magnification (e.g., 20x – 60x) using patented automatic objective changer.

Automation

Automate your processes by letting a lab robot handle the plate stacking for most efficient, high-end, 24/7 imaging experiments, including remote accessibility. Numerous established robots are supported.

Software

Application tools for analysis and visualization comprise statistical analysis and sub-population analysis for

  • Cell counting (incl. viability numbers and in colonies)
  • Translocation
  • Cell cycle
  • Cell morphology
  • Protein expression
  • Intracellular granules
  • Spheroids and 3D objects
  • Cytometry
  • Multiplexing
  • Cytoskeleton fiber analysis

Flexibility

Choose from a broad range of renowned air objectives, while using a variety of plates and sample formats.

  • up to 7 fluorescence colors
  • photobleaching (FRAP) with high-screening throughput
  • simultaneous acquisition mode for specific colors combinations
  • FRET protein-interaction experiments

Spheroids and 3D Imaging

High-Content Screening Workstation imaging

Research in drug discovery is increasingly relying on 3D organoid and spheroid cell cultures due to their enhanced reliability as indicators of in vivo efficacy and toxicity. However, the challenges posed by the high cellular density and larger size of these cultures compared to traditional 2D cell cultures make automated image analysis during microscopy-based screening more complex.

Applying robust algorithms to combined brightfield and multicolor fluorescence imaging, advanced software has been developed to morphometrically characterize each spheroid in multiple channels. This innovative approach provides insights into multiple cell types within each culture system, revealing spatial distributions of individual, categorized cells.

Utilizing widefield microscopy ensures fast acquisition and high throughput capacity, meeting the demands of large-scale drug screening trials. The resulting analyses yield multi-parametric growth curves that not only identify variations in growth patterns but also describe perturbed physiology and cytotoxicity in multiplexed assays.

Building upon these capabilities, our advanced software not only addresses the complexities associated with 3D organoid and spheroid cell cultures but also offers a comprehensive suite of features tailored to enhance every stage of the drug discovery process:

• Capture properly focused images of spheroids in their ideal growth environment in U-shape bottom plates

• Easily spot Spheroids using unique methodology of rapid scanning for spheroid localization

• Simple and labour reducing automated analysis of spheroid relevant features

• Monitor Spheroid growth over the entire plate using plate view

• Classify Spheroids of specific, desired features using sub-population tool

• Apply Live/ Dead Spheroid Assay to monitor viability of 3D tumour spheroids

• Visualize spheroid morphology over a range of depths using flexible multi-plane definitions

• Monitor Spheroid growth over the entire plate

Zebrafish Analysis Software

OMNI Life Science is proud to presentAthena Zebrafish– the next generation in Zebrafish assays. Our new, unique dedicated analysis software for automated analysis of Zebrafish microscopy images offers simple and quick quantification of fluorescence, measurement of morphological changes & other phenotypic features in Zebrafish larvae in a high throughput format.

Athena Zebrafishis suited for a broad range of researchers and accepts multiple image format types output from nearly all microscope manufacturers.

The software permits parameter-free zebrafish analysis using simple bright-field images. It automatically detects zebrafish embryos and larvae up to 5 days old (days post fertilization), extracting the fish contour and much of its internal anatomy: yolk sac, eye, notocord, and more, along with body regions of the head, trunk, and tail.

For each of these objects, the software measures the morphology (area, length, and shape) and can detect fluorescence in associated color channels. Both fluorescence intensity and spot/structure detection within specific anatomy are supported.

Rare Events

Contactone of our specialists and get a free trial of the Zebrafish Software.

Get in touch

Downloads

WiScan Brochure

WiScan Brochure

Athena Software Flyer

Athena Software Flyer

Hermes 24/7 Flyer

Hermes 24/7 Flyer

Hermes Zebrafish Screening Flyer

Hermes Zebrafish Screening Flyer

Hermes Product Family Brochure

Hermes Product Family Brochure

Hermes With Oil Objectives Brochure

Hermes With Oil Objectives Brochure