Rethink Cell Culture: Move Beyond 2D to More Predictive 3D Models
Traditional 2D cell culture forces cells to grow on a flat surface, lacking the complex 3D architecture, matrix interactions, and nutrient gradients found in vivo. As a result, 2D systems often fall short in accurately predicting drug efficacy and toxicity.
3D spheroids overcome these limitations by better mimicking natural tissues - supporting cell-cell communication, ECM formation, and realistic behaviors such as migration, differentiation, and long-term survival.
Organoids go even further. These self-organized, miniaturized organ models - derived from primary tissue, embryonic stem cells, or iPSCs - replicate key structural and functional features of organs, from brain and gut to kidney, lung, and retina.
A Next-Generation Approach to Reliable 3D Cell Culture
Scaffold-free, gentle, and highly reproducible
By providing precise control of temperature, pH, and CO₂ the innovative incubator and bioreactor CERO 3D creates an optimal environment for spheroids, organoids, stem cells, and tissue cultures—without the need for embedding substrates.
Key Benefits
- High cell viability and advanced maturation
- Gentle, shear-force-free cultivation
- Substrate-free, scaffold-free workflow
- Long-term culture possible for over one year with excellent homogeneity
- Simple setup with less than 2 minutes of daily hands-on time
This efficient solution dramatically reduces labor and operational costs while enabling robust and reproducible 3D cell culture for advanced research applications.
CERO 3D Incubator and Bioreactor
Experience Fast and Reliable Spheroid Formation
CEROplate, Ultra Low Attachment - available as 6 and 24 well plates (flat-bottom) and as 96 and 384 well plates (U-bottom).
Designed to address the challenges of spheroid culture, CEROplate ultra-low attachment, offers unmatched performance and reliability, setting a new standard in three-dimensional cell culture.
The ultra-low attachment CEROplate, simplifies the process for growing 3D aggregates. It features clear wells with U-bottom or flat-bottom to make sample
monitoring simple. The unique well geometry of the microplate aids in the formation of an unattached, round-shaped, single spheroid or organoid in the
center of each well. This allows to assay and analyze 3D aggregates in the same plate without transfer.
Invite our experts and lift your research to the next stage with a demo 3D CERO Incubator and Bioreactor from OLS
Join OLS and make your research reliable with our 3D CERO Incubator and Bioreactor with your lab-services as results.