CNTF is a survival factor for various neuronal cell types. CNTF seems to prevent the degeneration of motor axons after axotomy.
A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease.
Synonyms: HCNTF, CNTF, Ciliary Neurotrophic Factor

Storage Temperature: see datasheet

NT-3 a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. The protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo. NT-3 deficient mice generated by gene targeting display severe movement defects of the limbs.
The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
NT-3 human recombinant produced in E. coli is a non-glycosylated and non-covalently linked homodimer, containing 2x119 amino acid chains, having a total Mw of 27.2 kDa. The NT-3 is purified by proprietary chromatographic techniques.
Synonyms: Neurotrophic factor, NGF-2, HDNF

Storage Temperature: see datasheet

GDNF promotes the survival and differentiation of dopaminergic neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the RET proto-oncogene.
In addition to the transcript encoding GNDF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.
GDNF enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a homodimer, produce in E.Coli, non glykosylated, polypeptide chain containing 2x135 amino acids and having a total molecular mass of 30,360 Dalton. As a means of purifying GDNF, chromatographic techniques were used.
Synonyms: ATF1, ATF2, HFB1-GDNF

Storage Temperature: see datasheet

As its name suggested, NGF is involved primarily in the growth, as well as the maintenance, proliferation, and survival of nerve cells (neurons). Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. NGF subunits a and γ are members of the kallikrein family of serine proteases while the β subunit, called βNGF or 2.5S NGF, exhibits all the biological activities ascribed to NGF.
Synonyms: Beta nerve growth factor (NGF-beta), Beta Polypeptide, NGF, NGFB, HSAN5, Beta-NGF, MGC161426, MGC161428

Storage Temperature: see datasheet

Brain-derived neurotrophic factor (BDNF) promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. BDNF is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
BDNF human recombinant produced in E. coli is a homo-dimer, non-glycosylated polypeptide chain containing 2x119 amino acids and having a total molecular mass of 26,984 Dalton. BDNF human recombinant is purified by proprietary chromatographic techniques.
Synonyms: Brain-Derived Neurotrophic Factor, MGC34632

Storage Temperature: see datasheet