IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine.
This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Interleukin-4 Rat Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 125 amino acids and having a molecular mass of 14kDa. The IL-4 is purified by proprietary chromatographic techniques.
Synonyms: BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra.

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Interleukin-6 is a potent pro-inflammatory cytokine primarily produced by activated T cells and an assortment of other cells including endothelial cells and macrophages. IL-6 affects B and T lymphocytes and has been shown to have a role in host defense, acute phase reactions, immune responses and hematopoiesis.
Interleukin-6 Mouse Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 187 amino acids and having a molecular mass of 21709 Dalton. The IL-6 is purified by proprietary chromatographic techniques.
Synonyms: IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2, IL-6, Interleukin HP-1, B-cell hybridoma growth factor.

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IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Interleukin-13 Rat Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 113 amino acids and having a molecular mass of 12.7 kDa. The IL-13 is purified by proprietary chromatographic techniques.
Synonyms: NC300, ALRH, BHR1, P600, IL-13

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Interleukins are peptide hormones. This cytokines provide the communication between leucocyte and are involved in the immunological reaction. IL12 stimulates the production of IFNgamma from T-cells and natural killer cells, and also induces differentiation of Th1 helper cells. IL2 is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, Measles virus, and Human immunodeficiency virus (HIV).
Synonyms: NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-alpha, IL-12

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Interleukins are peptide hormones. This cytokines provide the communication between leucocyte and are involved in the immunological reaction. Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. IL-8 lures neutrophils, basophils, and T-cells, but not monocytes.
Synonyms: IL-8, CXCL8, Monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil-activating peptide, MONAP, Emoctakin, K60, NAF, LECT, LUCT, 3-10C, LYNAP, SCYB8, TSG-1, AMCF-I, b-ENAP

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Interleukin-1 beta (IL-1b) is produced by activated macrophages. IL-1b stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1b proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1b human recombinant produced in E. coli is a non-glycosylated, polypeptide chain containing 153 amino acids and having a molecular mass of 17,000 Dalton. The IL-1b is purified by proprietary chromatographic techniques.
Synonyms: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

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IL-1 alpha is produced by activated macrophages, stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. IL1A proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin from synovial cells.
Interleukin-1 alpha Human Recombinant produced in E. coli is single, a non-glycosylated, Polypeptide chain containing 159 amino acids and having a molecular mass of 18022 Dalton. The IL-1A is purified by proprietary chromatographic techniques.
Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL-1 alpha, IL1, IL-1A, IL1F1.

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IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of b-cells into ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
Interleukin-6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 184 amino acids and having a molecular mass of 21000 Dalton.
The IL-6 is purified by proprietary chromatographic techniques.
Synonyms: IFN-b2, B cell differentiation factor, BCDF, BSF-2, HPGF, HSF, MGI-2, B-cell stimulatory factor 2, Interferon beta-2, Hybridoma growth factor, CTL differentiation factor, CDF, IL-6, HGF

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Interleukin 2 (IL-2) is a powerful immune-regulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK-cells, lymphokine activated killer cells, monocytes, macrophages, and oligodendrocytes. Recombinant human IL-2 produced in E. coli is a 15.5 kDa protein, containing 134 amino acid residues including one intra-chain disulfide bond.
Synonyms: IL-2, Lymphokine, T-cell growth factor

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Interleukin 15 is a protein that regulates T and natural killer cell activation and proliferation. As a pleiotropic cytokine, it plays an important role in innate and adaptive immunity. Cytokines and interleukines share many biological activities.
IL-15 is constitutively expressed by a large number of tissues and cell types, including monocytes, macrophages, dendritic cells (DC), keratinocytes, fibroblasts and nerve cells.
They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6.
Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
Interleukin-15 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 114 amino acids (and an N-terminal Methionine) and having a molecular mass of 12.8kDa. The IL-15 is purified by proprietary chromatographic techniques.
Synonyms: Interleukin 15, IL-15, MGC9721

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IL10 is a cytokine produced primarily by monocytes and to a lesser extent by TH2-lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation.
IL 10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. It inhibits the formation of cytokines responsible for the Th1 answer thereby it promotes the survival, increase and the antibody production of B-lymphocytes.
It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway.
Synonyms: B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor

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IL4 is a pleiotropic cytokine produced by activated T cells, Th2 cells as well as mast cells. IL-4 is a Cytokine and Growth factor. IL4 is a ligand for interleukin 4 receptor.
His main function is the t-cell communication and leads there to various proliferation and differentiation. By his inhibitory effect on the function of macrophages, it belongs to anti-inflammatory cytokines.
Synonyms: BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra

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IL-3 is a potent growth promoting cytokine that promotes the survival, differentiation and proliferation of a broad range of hematopoetic cell types.
It is produced by T cells, mast cells, and eosinophils and enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Because of its ability to activate monocytes, it is supposed to have additional immunoregulatory roles. Many of the activities mentioned above are dependent on co-stimulation with other cytokines.
IL-3 produced in E. coli is single polypeptide chain containing 133 amino acids with a molecular mass of 15.0 kDa.
Synonyms: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulating factor, IL-3, hematopoetic growth factor

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