TNF alpha human rec.
Tumor necrosis factor alpha (TNF-a) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. TNF is mainly secreted by macrophages.
TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication. TNF is also involved in lipid metabolism and coagulation. The primary role of TNF is in the regulation of immune cells.
Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases - autoimmune diseases, insulin resistance, and cancer. TNF-a human recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 158 amino acids (157 amino acids of the mature human TNF-a and an N-terminal methionine) and having a molecular mass of 17.5 kDa. The TNF-a is purified by standard chromatographic techniques.
Synonyms: TNF-a, TNF-alpha, Tumor necrosis factor ligand super family member 2
Storage Temperature: see datasheet
Interne Referenz: CB-1112012
Specifications
| Size | 10 µg or 50 µg |